PHI i nytt sammanhang

Nedanstående info blev tillgängligt på nätet först denna vecka.
Jo,det har tydligen hållits ett symposium benämnt :

IXth International Symposium on Natural Products Chemistry and its Applications

Det har uppmärksammats i tidskriften Food and Chemical Toxicology.

I novemberutgåvan (2017-11) av tidskriften omnämns som sagt symposiet och där finns en studie med som heter:

Promising anticancer activity of Cyclotrichium niveum L. extracts through induction of both apoptosis and necrosis

Denna studie har bloggen uppmärksammat när den blev offentlig.

Hursom,författarna till den är forskare från Department of Pharmacology, Faculty of Pharmacy, Gazi University.

Ett universitet i Turkiet som är upptaget på PHI,s sida Users. Alltså en kund till Bolaget.

Utdrag ur forskningsrapporten:

Abstract

In this study, cytotoxic effects of the dichloromethane, ethyl acetate, ethanol, and aqueous extracts of the aerial parts of Cyclotrichium niveum (Boiss.) Manden. & Scheng (Lamiaceae) were evaluated. We tested HeLa, MCF-7 cancer cells, and MRC-5 and MCF-10A normal cells. The ethyl acetate and dichloromethane extracts induced cytotoxicity whereas the ethanol and aqueous extracts had no cytotoxic activity against both cancer cells. IC50 values of the dichloromethane extract were 353.0 ± 84.30 μg/ml, 114.8 ± 40.34 μg/ml, 39 ± 0.56 μg/ml, and 49 ± 13 μg/ml in HeLa, MCF-7, MRC-5, MCF-10A cells, respectively. IC50 values of the ethyl acetate extract were 117.0 ± 36.24 μg/ml in HeLa cells, 156.3 ± 19.86 μg/ml in MCF-7 cells, 1100 ± 340 μg/ml in MRC-5 cells and 7900 ± 1200 μg/ml in MCF-10A cells. Additionally, the ethyl acetate extract showed more selectivity to HeLa and MCF-7 cancer cells than MRC-5 and MCF-10A normal cells. Our results of HPLC analysis showed that apigeninin the ethyl acetate extract (2.2518 ± 0.0005 mg/100 mg extract) might be responsible of that selective cytotoxic effect. In the current work, we have shown for the first time that C. niveum has cytotoxic properties in the cancer cell lines tested.

Cell morphological changes were analyzed by Holostudio 2.4 software (Phase Holographic
Imaging AB, Phiab, Sweden). This label free technology detects the changes on cellular
morphology by using 3D holographic images.

Det intressanta här är sammanhanget PHI,via deras teknik omnämns.

Tidskriften beskriver sig själva enligt följande:

Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derivedproducts, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs.

The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter.

---------------------------------------------------------------------------------------------------------------------------------

Vanligtvis hittar vi PHI omnämnda i andra sammanhang än detta, Food and Chemical.

Bloggen tycker därför att detta är värt att uppmärksammas.