Bland forskarna ser vi den HoloMonitorfrälste Robert Horvath.
Studien finns enbart tillgänglig via dess abstract.
In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand
AbstractSALEN- and SALAN-based complexes with catalytically active metal centers are very promising small molecules to be utilized as part of antioxidant therapies.
Here we discuss a modified SALAN-type molecule armed with two phosphonate groups that significantly increase its water solubility and aid to furnish mono- or dinuclear complexes with Cu2+ ions. The regulation of the SOD-mimicking (i.e., catalytic) disproportionation reaction of the superoxide radical anion (O2•−) at pH ∼7.5 could be achieved by adjusting the metal-to-ligand stoichiometry as confirmed by McCord-Fridovich and pulse radiolysis tests.
The higher antioxidant activity of the dicopper complex can be explained by the better access of O2•− to the copper centers and their more positive Cu(II)/Cu(I) redox potential.
Simultaneously the analysis of in vitro effect on cells morphology indicates that cytotoxicity is also affected by the metal-to-ligand ratio, however, the active complex molecules do not show notable cytotoxicity that, together with the observed SOD-like activities, makes them potential candidates for antioxidant therapies.
Den offentligjordes i torsdags, Available online 4 April 2019, och hittas på denna sida som nr 5 bland övriga artiklar att publiceras.
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....Another novel, non-invasive technique for quantifying cytotoxicity is time-lapse cytometer HoloMonitor M4. This device is capable of recording cell morphological ...
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