Såhär beskriver man sin gärning :
- The FEBS Congress aims to provide an
outstanding international forum in the area of Europe and neighbouring
regions for the face to face exchange of knowledge and ideas across the
molecular life sciences.
The core scientific programme comprises inspiring plenary lectures from distinguished researchers working in areas of high topical interest, and a range of themed symposia providing focused updates from leading experts in each field. The contribution of participants towards the scientific discussion at the event is encouraged by the opportunity to present work through extensive poster sessions, and submitted abstracts may also be considered for oral presentations.
The broad subject coverage of the Congress and its size provide an excellent setting for participants to gain valuable insight into progress in research areas beyond their own. In addition, a range of special sessions aim to engage participants on wider issues, such as teaching in the molecular life sciences, and science and society questions. A commercial exhibition provides additional interest.
The FEBS Congress has a strong emphasis on support, education and inspiration for the next generation of scientists, with a bursary scheme for early-career researchers, a satellite Young Scientists’ Forum, and activities to encourage interaction with peers and experts.
Altogether the FEBS Congress aims to be an exemplary cross-discipline gathering in the molecular life sciences for research presentation, discussion, learning, inspiration and encouragement — with participants leaving with new research knowledge and ideas, and perhaps the beginnings of international collaborations and friendships.
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The FEBS Congress has become a unique collaboration between FEBS and its Constituent Societies (the biochemistry and molecular biology societies across Europe and neighbouring regions that belong to FEBS), with the organization of the event awarded to a different host Society each year. While the event retains the core elements that make it 'The FEBS Congress' (under the guidance of FEBS), this approach enables each host Society to bring a local flavour and fresh ideas to the meeting, and also gives opportunities for participants to explore new locations. Although always taking place in the FEBS area, the FEBS Congress attracts scientists from across the globe, and you do not need to be a member of a FEBS Constituent Society to take part.
På eventet presenterade forskare sina studier både muntligen och via posters.
PHI var inte där, men däremot representerade via forskare från Jagiellonian University Medical College, Krakow. Detta Uni använder sig av HoloMonitor i sin forskning (och finns med på PHI´s User-list).
6 forskare från detta Uni visade upp sina studier kring magcancer.
P06025
R. Szatanek, K. Węglarczyk, M. Stec, J. Baran, M. Siedlar, M. Baj-Krzyworzeka
Jagiellonian University Medical College, Krakow, Poland
Background: Tumorderived microvesicles (TMVs) interact with different cells of the immune system (lymphocytes, monocytes, dendritic cells, etc.) as well as tumorcells that they have originated from. In the present study, we examined the effect of autologousTMVs (autoTMVs) on gene expression, chemotaxis, intercellular signaling and cellular metabolism in cancer cells of the gastric cancer cell line 1415 (GC1415).
Methods: The effect of autoTMVs on mRNA gene expression profile in GC1415 cells was assessed using pathwayfocused PCR arrays.
Chemotaxis assay was performed using the HoloMonitor M4 System.
Signaling pathways were evaluated using Western blotting method.
Cellular respiration was measured using theSeahorse XF Cell Mito Stress Test.
Results: Exposure of GC1415 cells to autoTMVs led to the overexpression (75) and underexpression (96) of genes engaged in signal transduction, metabolism,chemotaxis, angiogenesis and metastasis.
The autoTMVs were able to induce chemotaxis and activate the PI3K/AKT, but not the MAPK/ERK, signaling pathway inGC1415 cells.
Moreover, studies on cellular respiration in GC1415 cells exposed to auto-TMVs revealed a metabolic shift towards glycolysis.
Conclusions: The obtained data support the clause that auto-TMVs, besides other types of extracellular vesicles (EVs), may exert a profound impact on tumor cellsfunctions.
Vi har en komplett forskningsrapport att se fram mot publiceras i det närmaste.
Mvh the99
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