Forskningsrapporten kommer finnas med i nästa nummer av tidskriften Experimental Cell Research, men finns tillgänglig i nätversionen redan nu.
Kostar dock $39.95 att låsa upp den om man inte vill vänta tills tidskriften kommer ut.
IBF är vana användare av PHI,s Holomonitor och finns upptagna på Bolagets lista Users.
De använder sig av förlagan till M4,alltså Holomonitor M3.
Men tillbaka till rapporten
Biophysical characterization of nanostructured TiO2 as a good substrate for hBM-MSC adhesion, growth and differentiation
L. Petecchia, C. Usai, M. Vassalli,P. GavazzoInstitute of Biophysics, National Research Council, Via De Marini 6, 16149 Genova, Italy
Received 22 February 2017, Revised 10 May 2017, Accepted 8 June 2017, Available online 13 June 2017
Abstract
Mesenchymal stem cells from human bone marrow (hBM-MSC)
are widely utilized for clinical applications involving bone healing.
In
this context, their use has been often optimized in association to
variously designed titanium substrates, being this material of great use
in orthopaedic implants.
According to recent
findings, the ability of hBM-MSC to differentiate towards a specific
lineage is not only driven by biochemical signals, but physical stimuli,
such as rigidity or roughness of the substrate, can also support a
commitment towards osteogenic differentiation.
Moreover, the presence of
features with defined dimensional scales, in particular nanometer-size,
also proved to elicit specific biological effects.
Here we evaluated
the effectiveness of a nano-patterned titanium surface in sustaining
hBM-MSC adhesion, growth and differentiation by means of a panel of
biophysical tools: morphometry, electrophysiology, intracellular calcium
measurements and immunocytochemistry.
The results substantiate the idea
that this micro-textured titanium dioxide is a good surface for growth
and differentiation of hBM-MSC and it exhibits a stimulating action
mainly in the initial period of differentiation. Moreover, the basal
concentration of free cytosolic Calcium [Ca2+]i is
confirmed to be a good hallmark of the hBM-MSC maturation stage.
The
study could provide relevant hints to help improving the
biocompatibility and osteointegration potential of clinical titanium
implants.
Info om bencancer
Primary bone cancers are not common and account for far less than 1% of
all cancers.
Bone cancers are more common in children and younger adults
than in older people.
Cancer found in the bones of an older adult
usually has spread to the bone after originating from another location
in the body.
Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and "secondary tumors" which originate in other sites and spread (metastasize) to the skeleton.
Carcinomas of the prostate, breasts, lungs, thyroid, and kidneys
are the carcinomas that most commonly metastasize to bone.
Secondary
malignant bone tumors are estimated to be 50 to 100 times as common as
primary bone cancers.
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| Stage 1A bone cancer |
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| Stage 1B bone cancer |
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| Stage 2A bone cancer |
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| Stage 2B bone cancer |
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| Stage 3 bone cancer |
Den uppmärksamme noterar att det är andra forskningsrapporten IBF får publicerad på kort tid.
Bloggen skrev 30/5 om deras första (?) forskningsrapport, A biophysical approach to quantify skeletal stem cells trans-differentiation as a model for the study of osteoporosis.
Nedanstående text framkommer vid sökning på aktuell rapport.
DH imaging was performed on hBM-MSC samples at different stage of osteo-differentiation by means of a HoloMonitor M3 microscope (PhaseHolographic Imaging, Lund, Sweden).
The M3 microscope provides ...
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