I Decemberutgåvan av den medicinska tidskriften Reproductive Toxicology kommer 20 kinesiska forskare publicera sin forskning rörande graviditet och tillhörande komplikationer.
Tidskriften rapporten presenteras i beskriver sig själva enligt:
Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction.
Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners.
Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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Fine particulate matter exposure induces cell cycle arrest and inhibits migration and invasion of human extravillous trophoblast, as determined by an iTRAQ-based quantitative proteomics strategy
Authors:
Zhe Qin; Haiyan Hou; Feng Fu; Jun Wu; Bin Han; Wen Yang; Liwen Zhang; Jin Cao; Xiaohan Jin; Shixiang Cheng; Zhen Yang; Min Zhang; Xiaoxia Lan; Ting Yao; Qulong Dong; Siyu Wu; Jingjing Zhang; Zhongwei Xu; Yuming Li; Yaqiong Chen
Pages: 10 - 22
Abstract: Publication date: December 2017
Source:Reproductive Toxicology, Volume 74
Long-term exposure to fine particulate matter (PM2.5) may cause adverse pregnancy outcomes but the mechanisms are not clear.
Our research confirms that PM2.5 induced DNA damage, and inhibited cell proliferation in HTR-8/SVneo cells, presenting in a dose- and time-dependent manners.
Using quantitative proteomics, the 182 and 486 differentially expressed proteins in cells treated with 120μgml−1 PM2.5 for 24 and 48h were involved in many critical biological processes, including of cell proliferation, response to DNA damage, regulation of small GTPase mediated signal transduction, and etc.
Further validation indicated that PM2.5 blocked the cell cycle at the G2/M phase through activation of the ATR-Cyclin E1/Cdk6 pathway, and it reduced the migration and invasion by upregulating TIMP1 and TIMP2 expression and downregulating Collagen I expression.
Our findings were consistent with the observed effects of PM2.5 on cell cycle arrest and inhibition of migration and invasion in human extravillous trophoblast.
Forskarnas rapport är låst så man kommer inte åt hela innehållet.
Men vid sökning på rapporten framgår det att man använt sig av PHI,s teknik, HoloMonitor.
"Three-dimensional images of cell morphology were constructed, and migration ability was analyzed by tracking the motion trail of each cell using HoloStudio 2.6.2 software."
Vill man grotta ner sig i alla funktioner HoloStudio 2.6.2 erbjuder klickar man på denna länk.
En av dessa enheter finns upptagen på PHI,s hemsida Users.
( Brain Research Center, Tianjin Hospital )
En detalj i sammanhanget är att Tianjin Medical University har ett samarbete med Karolinska Sjukhuset.
Min kommentar
Ännu en forskningsrapport från kinesiska forskare.Denna gång med forskning rörande graviditetskomplikationer.
Vi har sen tidigare sett rapporter rörande fertilitetsproblematik beträffande mäns spermier, men detta område är nytt för mig.
Jag upprepar mig själv nu, men kineserna har verkligen hittat användningsområden för holotekniken.
Det stärker mig än mer i min spekulation beträffande det Kinesiska Pusslet.
Jag har en motivbild ytterligare som jag ska granska lite närmare framöver.
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