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Phase Holographic Imaging introduces HoloMonitor® NG—our next-generation, adaptable QPI platform for live cell imaging. With a redesigned hardware architecture and significantly improved software, we deliver an instrument with fourfold higher resolution and more accurate, automated segmentation. Built with clinical workflows in mind, HoloMonitor NG is engineered to meet the rigorous requirements set by clinical settings. 

Enhanced segmentation for reliable data

With cleaner, higher-resolution holograms and reduced noise, our software team has been able to develop an updated reconstruction algorithm that produces more reliable quantitative phase images and a more robust assessment of image quality. In parallel, the stronger signal and increased detail in the reconstructed images have enabled major advances in segmentation.

The new segmentation algorithms are more accurate and consistent across varying cell morphologies, and provides automated cell segmentation for reduced manual intervention. This makes it easier to set up assays and obtain reproducible single-cell measurements at scale—especially in challenging samples where thin or low-contrast cells previously limited performance.

HoloMonitor NG is prepared for AI-enabled workflows, allowing users to train AI-driven segmentation models on their own unique cell types. This enables even greater automation and more reliable, consistent segmentation across experiments.

Redesigned hardware improves image quality for thin cells 

Pre-clinical and clinical studies

HoloMonitor NG has been used in an ongoing clinical study of uncontrolled asthma to track wound closure, morphology, and migration in patient-derived bronchial epithelial cells—continuously and label-free using quantitative phase imaging. Early exploratory observations highlight the potential of holographic live-cell imaging as a functional complement to established clinical biomarkers.

Together with a partner at Wake Forest Institute of Regenerative Medicine (WFIRM) in Winston Salem, NC, USA, we study human primary placental cells. These very thin cells have been challenging but going forward, HoloMonitor NG will facilitate imaging and analysis.

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